Blar i forfatter "Song, Xiaobo"

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    • B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1 

      Zhou, Humin; Ma, Hongye; Wei, Wei; Ji, Donghua; Song, Xiaobo; Sun, Jinglu; Zhang, Jianing; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      b-1, 4-Galactosyltransferase gene (B4GALT) family consists of seven members, which encode corresponding enzymes known as type II membrane-bound glycoproteins. These enzymes catalyze the biosynthesis of different glycoconjugates and saccharide structures, and have been recognized to be involved in various diseases. In this study, we sought to determine the expressional profiles of B4GALT family ...

    • Characterisation of the Plasmidome within Enterococcus faecalis Isolated from Marginal Periodontitis Patients in Norway 

      Song, Xiaobo; Sun, Jinglu; Mikalsen, Theresa; Roberts, Adam P.; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The present study aimed to identify and characterize plasmids in a national collection of oral Enterococcus faecalis (n = 106) isolated from patients with marginal periodontitis. Plasmid replicon typing was performed by multiplex-PCR and sequencing with specific primers for 18 rep-families and 1 unique sequence. Additional plasmid analysis by S1-PFGE was performed for comparison. Totally 120 plasmid ...

    • Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis(RAS)-affected patients 

      Yang, Zhongjun; Cui, Qingyu; An, Ran; Wang, Juan; Song, Xiaobo; Shen, Yu; Wang, Mingyu; Xu, Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-29)
      <i>Background</i> - Recurrent aphthous stomatitis (RAS) is the most common form of oral ulcerative disease, whose cause is still unknown. Researchers have found the association of many factors with the occurrence of RAS, and proposed oral bacterial infection could be a cause for this disease.<p> <p><i>Methods</i> - To investigate whether the occurrence of RAS is associated with oral bacterial ...

    • Comprehensive N-glycan profiles of hepatocellular carcinoma reveal association of fucosylation with tumor progression and regulation of FUT8 by microRNAs 

      Cheng, Lei; Gao, Shuhang; Song, Xiaobo; Dong, Weijie; Zhou, Huimin; Zhao, Lifen; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Glycosylation has significant effects on cancer progression. Fucosylation is one of the most important glycosylation events involved in hepatocellular carcinoma (HCC). Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating ...

    • The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers 

      Andriukaitiene, Laura; Song, Xiaobo; Yang, Nannan; Lippo V. J., Lassila; K. Vallittu, Pekka; Kerosuo, Eero (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <p><i>Background</i>: The aim of the study was to assess bacterial sealability and bonding ability of methacrylate-based Resilon (RS, SybronEndo), Endo Rez (ER, Ultradent Products Inc), and epoxy-based AH Plus (AH, Dentsply/DeTrey), MTA Fill Apex (MTAF, Angelus Soluções Odontológicas) root canal sealers, and the effect of the smear layer removal on the sealability.</p> <p><i>Methods</i>: One ...

    • The Genetic Structures of an Extensively Drug Resistant (XDR) Klebsiella pneumoniae and its Plasmids 

      Li, Ling; Yu, Tao; Ma, Yanan; Yang, Zhongjun; Wang, Wenjia; Song, Xiaobo; Shen, Yu; Guo, Tingting; Kong, Jian; Wang, Mingyu; Xu, Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-04)
      Multi-, extensively-, and pan-drug resistant bacteria are a threat to our health today, because their wide resistance spectra make their infections difficult to cure. In this work, we isolated an extensively drug resistant (XDR) <i>Klebsiella pneumoniae</i> 2-1 strain from the stool sample of a patient diagnosed of colorectal cancer. <i>K. pneumoniae</i> 2-1 was found to be resistant to all the ...

    • Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo 

      Liu, Yinhui; Song, Xiaobo; Zhou, Huimin; Zhou, Xue; Xia, Yunlong; Dong, Xin; Zhong, Wei; Tang, Shaoying; Wang, Lili; Wen, Shu; Xiao, Jing; Tang, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      Background: Statin has been widely used to treat hyperlipidemia because of its high potency in decreasing cholesterol levels. The present study aimed to examine the lipid-lowering effect of rosuvastatin and the composition, diversity and species abundance of gut microbiome in association with rosuvastatin efficacy. <br> <br> TRIAL REGISTRATION: ChiCTR-ORC-17013212 at the First Affiliated Hospital ...

    • Microbiome Structure and Mucosal Morphology of Jejunum Appendix and Colon of Rats in Health and Dysbiosis 

      Shao, Chenyi; Song, Xiaobo; Wang, Lili; Zhang, Hongying; Liu, Yinhui; Wang, Chunhao; Chen, Shenmin; Ren, Baowei; Wen, Shu; Xiao, Jing; Tang, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)
      Gut microbiota contributes to human health. Plenty of studies demonstrate that antibiotics can disrupt gut ecosystem leading to dysbiosis. Little is known about the microbial variation of appendix and its up/downstream intestine after antibiotic treatment. This study aimed to investigate the microbiome and mucosal morphology of jejunum, appendix, and colon of rats in health and dysbiosis. A rodent ...

    • MiR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4 

      Zhao, Lifen; Feng, Xiaobin; Song, Xiaobo; Zhou, Humin; Zhao, Yongfu; Cheng, Lei; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-16)
      Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV ...

    • Reversal effect of ST6GAL 1 on multidrug resistance in human leukemia by regulating the PI3K/Akt pathway and the expression of P-gp and MRP1 

      Ma, Hongye; Cheng, Lei; Hao, Keji; Li, Yanping; Song, Xiaobo; Zhou, Huimin; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1 

      Moens, Ugo; Song, Xiaobo; Van Ghelue, Marijke; Lednicky, John A.; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)
      Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the ...

    • Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia 

      Zhao, Lifen; Li, Yan; Song, Xiaobo; Zhou, Huimin; Li, Nana; Miao, Yuan; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Chemotherapy resistance frequently drives tumor progression. Increased expression of ST8SIA4 has been reported in diverse carcinomas and highly correlates with leukemia multidrug resistance (MDR). MicroRNAs (miRNA) are widely recognized as key players in cancer progression and drug resistance. Here, to explore whether miRNA modulates the sensitivity of chronic myelocytic leukemia (CML) to chemotherapeutic ...